There has been a lot of buzz around the recently discovered MTHFR gene variants. MTHFR is a gene that provides instructions for making an enzyme called MethyleneTetrahydrofolate Reductase. This enzyme adds a methyl group to folate to make it usable by the body. Those with the gene mutation may have trouble effectively eliminating toxins from the body. Though it is estimated that 40% of people have the MTHFR mutation, severe MTHFR deficiency is a rare, recessive condition.


While there is a considerable amount of information coming out on genetic variations and how they affect our biochemistry and health, the MTHFR deficiency is not yet fully understood. There seems to be some evidence that Folinic Acid is safe for those with the less severe MTHFR gene variants. Preliminary studies show that those with severe MTHFR deficiencies may require 5-MTHF (Methylated Folate) supplementation and/or treatment with betaine. 


In clinical settings, betaine is the main treatment used with severe MTHFR deficiency. Betaine is an amino acid that works as a methyl donor. Betaine supplementation has proven effective in clinical studies with patients who have the MTHFR deficiency. While our Morning Multivitamins contain Betaine, they do not contain a sufficient amount to account for the deficiency, and are not meant to be a treatment for MTHFR deficiency. 


If you are aware that you carry the MTHFR gene mutation, we highly recommend that you speak with your physician or healthcare professional for their advice on what is best for you.